From Cleveland/Akron, Canton:

Take I-77 S. to St. Rte. 36 W. Get on St. Rte. 16 W in Coshocton and then go south on St. Rte. 60.
 
From Youngstown/Warren:
Take I-76/80 W. to I-77 S., and follow the directions
above.
 
From Columbus/Dayton:
Take I-70 E. to Zanesville and get on St. Rte. 60 N.
 
From Toledo:
Take I-75 S. to U.S. Rte. 23S. to the outskirts
of Columbus. Take I-270 E. to I-70 E.
In Zanesville, take St. Rte. 60 N.
 
From Cincinnati:
Take I-71 N to I-70 E. .
In Zanesville get on St. Rte. 60 N
 
From Marietta:
Take I-77 N. to I-70 W.
In Zanesville, get on St. Rte. 60 N.